Julian Assange's doctors say his health is at risk as a result of his six-year confinement in the Ecuadorian embassy in London.
Sondra S Crosby, Brock Chisholm and Sean Love, writing on The Guardian's website, said that they spent 20 hours over three days assessing Assange's condition.
Without giving any particular details, they said that his confinement has had an impact on his physical and mental health.
The WikiLeaks founder has not stepped out of the Knightsbridge, west London, embassy since August 2012, when he was granted asylum by Ecuador.
He had breached his bail conditions amid sex-related allegations in Sweden for which he was due to be extradited.
Sweden dropped the investigation in May 2017 and applied to revoke the European arrest warrant.
However, he may still be arrested by UK police if he steps outside of the embassy for breaking his bail conditions in 2012.
"As clinicians, it is our ethical duty to advocate for the health and human rights of all people as promised under international law," wrote the doctors.
"Experience tells us that the prolonged uncertainty of indefinite detention inflicts profound psychological and physical trauma above and beyond the expected stressors of incarceration.
"These can include severe anxiety, pathological levels of stress, dissociation, depression, suicidal thoughts, post-traumatic stress disorder and chronic pain, among others.
"It is unconscionable that Mr Assange is in the position of having to decide between avoiding arrest and potentially suffering the health consequences, including death, if a life-threatening crisis such as a heart attack were to occur.
"Further, our assessment reveals that he has had no access to sunlight, appropriate ventilation or outside space for over five and a half years."
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Meanwhile, Ecuador's president Lenin Moreno has indirectly called Wikileaks Assange a nuisance.
Assange is "like a stone in your shoe," Moreno told reporters in Quito on Wednesday.
"Without a doubt, it is a stone in the shoe. We do not generate it, we inherit it," the Ecuadorian president said.
"Some solution must be found."
He also said he had talked with the UK ambassador in Ecuador, Catherine Ward, whom he said "agreed" that a way out must be found "so that at the same time Mr Assange protects his life and can be punished for the mistake he made."
Removing Assange from the embassy was not in line with the principles of Ecuador, Moreno added.
With PA
